MovDisordV3, Main, Exploration, bibRecord, 002508

Muscle Biopsy Substantiates Long-Term MRI Alterations One Year After A Single Dose of Botulinum Toxin Injected into the Lateral Gastrocnemius Muscle of Healthy Volunteers

Identifieur interne : 002508 ( Main/Exploration ); précédent : 002507; suivant : 002509

Muscle Biopsy Substantiates Long-Term MRI Alterations One Year After A Single Dose of Botulinum Toxin Injected into the Lateral Gastrocnemius Muscle of Healthy Volunteers

Auteurs : A. Sebastian Schroeder [Allemagne] ; Birgit Ertl-Wagner [Allemagne] ; Stefanie Britsch [Allemagne] ; J. Michael Schroder [Allemagne] ; Stefan Nikolin [Allemagne] ; Joachim Weis [Allemagne] ; Wolfgang Müller-Felber [Allemagne] ; Inga Koerte [Allemagne] ; Maximilian Stehr [Allemagne] ; Steffen Berweck [Allemagne] ; Ingo Borggraefe [Allemagne] ; Florian Heinen [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0358925

Descripteurs français

Pascal (Inist)
- Atrophie, Pathologie du système nerveux, Biopsie, Long terme, Imagerie RMN, Dose unique, Bontoxilysin, Muscle gastrocnémien, Homme, Intensité élevée, Jonction neuromusculaire.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Atrophy, Biopsy, Bontoxilysin, Gastrocnemius muscle, High intensity, Human, Long term, Nervous system diseases, Neuromuscular junction, Nuclear magnetic resonance imaging, Single dose.

Abstract

Despite numerous clinical and experimental studies on botulinum toxin type A (BoNT/A), long-term alterations of muscle texture and fine structure following BoNT/A treatment have thus far not been studied in normal human skeletal muscle. After obtaining institutional review board approval, we performed a prospective, placebo-controlled, double-blinded follow-up study on two healthy adults using magnetic resonance imaging (MRI) and muscle biopsy to visualize long-term alterations after a single BoNT/A injection into the lateral head of the gastrocnemius muscle. MRI disclosed a high-signal-intensity pattern in short tau inversion recovery sequences, and a reduction of the cross-sectional area in the BoNT/A-injected, but not in the saline-injected contralateral control muscle (at 6 to 9 months in volunteer A: 73%, in B: 62%; at 12 months in A: 88%, and in B: 78%). Enzyme histochemistry, 12 months after injection, confirmed neurogenic atrophy of muscle fibers only in the BoNT/A-injected muscle. Electron microscopy revealed additional degenerative changes at the neuromuscular junction. The data confirm that MRI is a suitable tool to monitor the long-term effect of BoNT/A on skeletal muscle. Neurogenic muscle atrophy following a single BoNT/A injection should be taken into consideration when repeated BoNT/A injections into the same muscles are proposed.

Affiliations:

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Muscle Biopsy Substantiates Long-Term MRI Alterations One Year After A Single Dose of Botulinum Toxin Injected into the Lateral Gastrocnemius Muscle of Healthy Volunteers</title>
<author><name sortKey="Sebastian Schroeder, A" sort="Sebastian Schroeder, A" uniqKey="Sebastian Schroeder A" first="A." last="Sebastian Schroeder">A. Sebastian Schroeder</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Pediatric Neurology and Developmental Medicine, Dr. von Hauner's Children's Hospital, University of Munich</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
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<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
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<author><name sortKey="Ertl Wagner, Birgit" sort="Ertl Wagner, Birgit" uniqKey="Ertl Wagner B" first="Birgit" last="Ertl-Wagner">Birgit Ertl-Wagner</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Institute of Clinical Radiology, University of Munich</s1>
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<author><name sortKey="Britsch, Stefanie" sort="Britsch, Stefanie" uniqKey="Britsch S" first="Stefanie" last="Britsch">Stefanie Britsch</name>
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<region type="district" nuts="2">District de Haute-Bavière</region>
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<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
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<author><name sortKey="Schroder, J Michael" sort="Schroder, J Michael" uniqKey="Schroder J" first="J. Michael" last="Schroder">J. Michael Schroder</name>
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<author><name sortKey="Muller Felber, Wolfgang" sort="Muller Felber, Wolfgang" uniqKey="Muller Felber W" first="Wolfgang" last="Müller-Felber">Wolfgang Müller-Felber</name>
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<author><name sortKey="Koerte, Inga" sort="Koerte, Inga" uniqKey="Koerte I" first="Inga" last="Koerte">Inga Koerte</name>
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<author><name sortKey="Stehr, Maximilian" sort="Stehr, Maximilian" uniqKey="Stehr M" first="Maximilian" last="Stehr">Maximilian Stehr</name>
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<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
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<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
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<author><name sortKey="Berweck, Steffen" sort="Berweck, Steffen" uniqKey="Berweck S" first="Steffen" last="Berweck">Steffen Berweck</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Pediatric Neurology and Developmental Medicine, Dr. von Hauner's Children's Hospital, University of Munich</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
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<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
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<author><name sortKey="Borggraefe, Ingo" sort="Borggraefe, Ingo" uniqKey="Borggraefe I" first="Ingo" last="Borggraefe">Ingo Borggraefe</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Pediatric Neurology and Developmental Medicine, Dr. von Hauner's Children's Hospital, University of Munich</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
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<author><name sortKey="Heinen, Florian" sort="Heinen, Florian" uniqKey="Heinen F" first="Florian" last="Heinen">Florian Heinen</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Pediatric Neurology and Developmental Medicine, Dr. von Hauner's Children's Hospital, University of Munich</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atrophy</term>
<term>Biopsy</term>
<term>Bontoxilysin</term>
<term>Gastrocnemius muscle</term>
<term>High intensity</term>
<term>Human</term>
<term>Long term</term>
<term>Nervous system diseases</term>
<term>Neuromuscular junction</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Single dose</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Atrophie</term>
<term>Pathologie du   système nerveux</term>
<term>Biopsie</term>
<term>Long terme</term>
<term>Imagerie RMN</term>
<term>Dose unique</term>
<term>Bontoxilysin</term>
<term>Muscle gastrocnémien</term>
<term>Homme</term>
<term>Intensité élevée</term>
<term>Jonction neuromusculaire</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Despite numerous clinical and experimental studies on botulinum toxin type A (BoNT/A), long-term alterations of muscle texture and fine structure following BoNT/A treatment have thus far not been studied in normal human skeletal muscle. After obtaining institutional review board approval, we performed a prospective, placebo-controlled, double-blinded follow-up study on two healthy adults using magnetic resonance imaging (MRI) and muscle biopsy to visualize long-term alterations after a single BoNT/A injection into the lateral head of the gastrocnemius muscle. MRI disclosed a high-signal-intensity pattern in short tau inversion recovery sequences, and a reduction of the cross-sectional area in the BoNT/A-injected, but not in the saline-injected contralateral control muscle (at 6 to 9 months in volunteer A: 73%, in B: 62%; at 12 months in A: 88%, and in B: 78%). Enzyme histochemistry, 12 months after injection, confirmed neurogenic atrophy of muscle fibers only in the BoNT/A-injected muscle. Electron microscopy revealed additional degenerative changes at the neuromuscular junction. The data confirm that MRI is a suitable tool to monitor the long-term effect of BoNT/A on skeletal muscle. Neurogenic muscle atrophy following a single BoNT/A injection should be taken into consideration when repeated BoNT/A injections into the same muscles are proposed.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Bavière</li>
<li>District de Cologne</li>
<li>District de Haute-Bavière</li>
<li>Rhénanie-du-Nord-Westphalie</li>
</region>
<settlement><li>Aix-la-Chapelle</li>
<li>Munich</li>
</settlement>
<orgName><li>Université Louis-et-Maximilien de Munich</li>
</orgName>
</list>
<tree><country name="Allemagne"><region name="Bavière"><name sortKey="Sebastian Schroeder, A" sort="Sebastian Schroeder, A" uniqKey="Sebastian Schroeder A" first="A." last="Sebastian Schroeder">A. Sebastian Schroeder</name>
</region>
<name sortKey="Berweck, Steffen" sort="Berweck, Steffen" uniqKey="Berweck S" first="Steffen" last="Berweck">Steffen Berweck</name>
<name sortKey="Borggraefe, Ingo" sort="Borggraefe, Ingo" uniqKey="Borggraefe I" first="Ingo" last="Borggraefe">Ingo Borggraefe</name>
<name sortKey="Britsch, Stefanie" sort="Britsch, Stefanie" uniqKey="Britsch S" first="Stefanie" last="Britsch">Stefanie Britsch</name>
<name sortKey="Ertl Wagner, Birgit" sort="Ertl Wagner, Birgit" uniqKey="Ertl Wagner B" first="Birgit" last="Ertl-Wagner">Birgit Ertl-Wagner</name>
<name sortKey="Heinen, Florian" sort="Heinen, Florian" uniqKey="Heinen F" first="Florian" last="Heinen">Florian Heinen</name>
<name sortKey="Koerte, Inga" sort="Koerte, Inga" uniqKey="Koerte I" first="Inga" last="Koerte">Inga Koerte</name>
<name sortKey="Muller Felber, Wolfgang" sort="Muller Felber, Wolfgang" uniqKey="Muller Felber W" first="Wolfgang" last="Müller-Felber">Wolfgang Müller-Felber</name>
<name sortKey="Nikolin, Stefan" sort="Nikolin, Stefan" uniqKey="Nikolin S" first="Stefan" last="Nikolin">Stefan Nikolin</name>
<name sortKey="Schroder, J Michael" sort="Schroder, J Michael" uniqKey="Schroder J" first="J. Michael" last="Schroder">J. Michael Schroder</name>
<name sortKey="Stehr, Maximilian" sort="Stehr, Maximilian" uniqKey="Stehr M" first="Maximilian" last="Stehr">Maximilian Stehr</name>
<name sortKey="Weis, Joachim" sort="Weis, Joachim" uniqKey="Weis J" first="Joachim" last="Weis">Joachim Weis</name>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Muscle Biopsy Substantiates Long-Term MRI Alterations One Year After A Single Dose of Botulinum Toxin Injected into the Lateral Gastrocnemius Muscle of Healthy Volunteers

Muscle Biopsy Substantiates Long-Term MRI Alterations One Year After A Single Dose of Botulinum Toxin Injected into the Lateral Gastrocnemius Muscle of Healthy Volunteers

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